Publications

2025

• Morales LC, Kim CD, Pan Y, Scheuring S, Gonzalez AL. Engineered microvascular basement membrane mimetic for real-time neutrophil tracking in the microvascular wall. Bioeng Transl Med. 2025 Mar 12;10(4):e70008. doi: 10.1002/btm2.70008.                                                                                                                                                                                                               

• Ijaz N, Nader M, Ponticiello M, Vance AJ, van de Water BJ, Funaro MC, Abbas Q, Adabie Appiah J, Chisti MJ, Commerell W, Elvis Dzelamunyuy S, Martinez Fernandez R, Gonzalez AL, Johnston C, Luckson Kaiwe E, Kaur M, Lang HJ, McCollum ED, Marcos González Moraga J, Muralidharan J, Renning K, Tan HL, Alejandra Vélez Ruiz Gaitán L, González-Dambrauskas S, Wilson PT, Morrow BM, Davis JL. Contextual factors influencing bubble continuous positive airway pressure implementation for paediatric respiratory distress in low-income and middle-income countries: a realist review. Lancet Glob Health. 2025 Feb;13(2):e232-e245. doi: 10.1016/S2214-109X(24)00453-4.

2024

• Gudneppanavar R, Di Pietro C, H Öz H, Zhang PX, Cheng EC, Huang PH, Tebaldi T, Biancon G, Halene S, Hoppe AD, Kim C, Gonzalez AL, Krause DS, Egan ME, Gupta N, Murray TS, Bruscia EM. Ezrin drives adaptation of monocytes to the inflamed lung microenvironment. Cell Death Dis. 2024 Nov 29;15(11):864. doi: 10.1038/s41419-024-07255-8.      

• Jiang Q, Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani MN, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X, Mani A, Gonzalez A, Goodwin JE, Sessa WC, Ishibe S, Jane-Wit D. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Kidney Int. 2024 Sep;106(3):419-432. doi: 10.1016/j.kint.2024.05.007.   

• Pellowe AS, Wu MJ, Kang TY, Chung TD, Ledesma-Mendoza A, Herzog E, Levchenko A, Odell I, Varga J, Gonzalez AL. TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease. Am J Pathol. 2024 Jul;194(7):1171-1184. doi: 10.1016/j.ajpath.2024.02.021.                                                                                                                                                                                                                                                                    

• Meizlish ML, Kimura Y, Pope SD, Matta R, Kim C, Philip NH, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Sci Adv. 2024 Mar 15;10(11):eadk6906. doi: 10.1126/sciadv.adk6906.

2022

• Cable J, Arlotta P, Parker KK, Hughes AJ, Goodwin K, Mummery CL, Kamm RD, Engle SJ, Tagle DA, Boj SF, Stanton AE, Morishita Y, Kemp ML, Norfleet DA, May EE, Lu A, Bashir R, Feinberg AW, Hull SM, Gonzalez AL, Blatchley MR, Montserrat Pulido N, Morizane R, McDevitt TC, Mishra D, Mulero-Russe A. Engineering multicellular living systems-a Keystone Symposia report. Ann N Y Acad Sci. 2022 Dec;1518(1):183-195. doi: 10.1111/nyas.14896.

2021

• Matta R, Feng Y, Sansing LH, Gonzalez AL. Endothelial cell secreted VEGF-C enhances NSC VEGFR3 expression and promotes NSC survival. Stem Cell Res. 2021 May;53:102318. doi: 10.1016/j.scr.2021.102318.

• Gonzalez Porras MA, Stojkova K, Vaicik MK, Pellowe A, Goddi A, Carmona A, Long B, Qutub AA, Gonzalez A, Cohen RN, Brey EM. Integrins and extracellular matrix proteins modulate adipocyte thermogenic capacity. Sci Rep. 2021 Mar 8;11(1):5442. doi: 10.1038/s41598-021-84828-z.

• Khan SN, Han P, Chaudhury R, Bickerton S, Lee JS, Calderon B, Pellowe A, Gonzalez A, Fahmy T. Direct Comparison of B Cell Surface Receptors as Therapeutic Targets for Nanoparticle Delivery of BTK Inhibitors. Mol Pharm. 2021 Mar 1;18(3):850-861. doi: 10.1021/acs.molpharmaceut.0c00836.

• Matta R, Yousafzai MS, Murrell M, Gonzalez AL. Endothelial cell secreted metalloproteinase-2 enhances neural stem cell N-cadherin expression, clustering, and migration. FASEB J. 2021 Feb;35(2):e21311. doi: 10.1096/fj.202002302RR.

• Ghuman H, Matta R, Tompkins A, Nitzsche F, Badylak SF, Gonzalez AL, Modo M. ECM hydrogel improves the delivery of PEG microsphere-encapsulated neural stem cells and endothelial cells into tissue cavities caused by stroke. Brain Res Bull. 2021 Mar;168:120-137. doi: 10.1016/j.brainresbull.2020.12.004.

• Krishnan S, Suarez-Martinez AD, Bagher P, Gonzalez A, Liu R, Murfee WL, Mohandas R. Microvascular dysfunction and kidney disease: Challenges and opportunities? Microcirculation. 2021 Apr;28(3):e12661. doi: 10.1111/micc.12661.

2020-2004

• Korde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, Gomez JL, Chupp G, Pober JS, Gonzalez A, Takyar SS. An endothelial microRNA-1-regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis. J Allergy Clin Immunol. 2020 Feb;145(2):550-562. doi: 10.1016/j.jaci.2019.10.031.

• Matta R, Lee S, Genet N, Hirschi KK, Thomas JL, Gonzalez AL. Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone. Sci Rep. 2019 Nov 28;9(1):17798. doi: 10.1038/s41598-019-54167-1. Erratum in: Sci Rep. 2020 Jan 14;10(1):621. doi: 10.1038/s41598-020-57577-8.

• Matta R, Gonzalez AL. Engineered Biomimetic Neural Stem Cell Niche. Curr Stem Cell Rep. 2019;5(3):109-114. doi: 10.1007/s40778-019-00161-2.

• Pellowe AS, Sauler M, Hou Y, Merola J, Liu R, Calderon B, Lauridsen HM, Harris MR, Leng L, Zhang Y, Tilstam PV, Pober JS, Bucala R, Lee PJ, Gonzalez AL. Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation. FASEB J. 2019 Feb;33(2):2171-2186. doi: 10.1096/fj.201800480R.

• Matta R, Gonzalez AL. Stroke Repair via Biomimicry of the Subventricular Zone. Frontiers in Materials. 2018 Mar; 15(5). doi: 10.3389/fmas.2018.00015.

• Pellowe AS, Lauridsen HM, Matta R, Gonzalez AL. Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture. J Vis Exp. 2017 Dec 26;(130):56384. doi: 10.3791/56384.

• Sava P, Ramanathan A, Dobronyi A, Peng X, Sun H, Ledesma-Mendoza A, Herzog EL, Gonzalez AL. Human pericytes adopt myofibroblast properties in the microenvironment of the IPF lung. JCI Insight. 2017 Dec 21;2(24):e96352. doi: 10.1172/jci.insight.96352.

• Ryu C, Sun H, Gulati M, Herazo-Maya JD, Chen Y, Osafo-Addo A, Brandsdorfer C, Winkler J, Blaul C, Faunce J, Pan H, Woolard T, Tzouvelekis A, Antin-Ozerkis DE, Puchalski JT, Slade M, Gonzalez AL, Bogenhagen DF, Kirillov V, Feghali-Bostwick C, Gibson K, Lindell K, Herzog RI, Dela Cruz CS, Mehal W, Kaminski N, Herzog EL, Trujillo G. Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2017 Dec 15;196(12):1571-1581. doi: 10.1164/rccm.201612-2480OC.

• Lauridsen HM, Pellowe AS, Ramanathan A, Liu R, Miller-Jensen K, McNiff JM, Pober JS, Gonzalez AL. Tumor Necrosis Factor-α and IL-17A Activation Induces Pericyte-Mediated Basement Membrane Remodeling in Human Neutrophilic Dermatoses. Am J Pathol. 2017 Aug;187(8):1893-1906. doi: 10.1016/j.ajpath.2017.04.008.

• Lauridsen HM, Gonzalez AL. Biomimetic, ultrathin and elastic hydrogels regulate human neutrophil extravasation across endothelial-pericyte bilayers. PLoS One. 2017 Feb 24;12(2):e0171386. doi: 10.1371/journal.pone.0171386.

• Liu R, Lauridsen HM, Amezquita RA, Pierce RW, Jane-Wit D, Fang C, Pellowe AS, Kirkiles-Smith NC, Gonzalez AL, Pober JS. IL-17 Promotes Neutrophil-Mediated Immunity by Activating Microvascular Pericytes and Not Endothelium. J Immunol. 2016 Sep 15;197(6):2400-8. doi: 10.4049/jimmunol.1600138.

• Sun H, Zhu Y, Pan H, Chen X, Balestrini JL, Lam TT, Kanyo JE, Eichmann A, Gulati M, Fares WH, Bai H, Feghali-Bostwick CA, Gan Y, Peng X, Moore MW, White ES, Sava P, Gonzalez AL, Cheng Y, Niklason LE, Herzog EL. Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis. Arthritis Rheumatol. 2016 May;68(5):1251-61. doi: 10.1002/art.39575.

• Pellowe AS, Gonzalez AL. Extracellular matrix biomimicry for the creation of investigational and therapeutic devices. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jan-Feb;8(1):5-22. doi: 10.1002/wnan.1349.

• Brown L, Sava P, Garcia C, Gonzalez AL. Proteomic Analysis of Pericyte Derived Extracellular Matrix. Cellular and Molecular Bioengineering; 8(3): 349-363. 2015. doi: 10.1007/s12195-015-0408-5

• Sava P, Cook IO, Mahal RS, Gonzalez AL. Human microvascular pericyte basement membrane remodeling regulates neutrophil recruitment. Microcirculation. 2015 Jan;22(1):54-67. doi: 10.1111/micc.12173.

• Kim HY, Skokos EA, Myer DJ, Agaba P, Gonzalez AL. α_Vβ₃ Integrin Regulation of Respiratory Burst in Fibrinogen Adherent Human Neutrophils. Cell Mol Bioeng. 2014 Jun;7(2):231-242. doi: 10.1007/s12195-014-0322-2.

• Gonzalez AL, Berger CL, Remington J, Girardi M, Tigelaar RE, Edelson RL. Integrin-driven monocyte to dendritic cell conversion in modified extracorporeal photochemotherapy. Clin Exp Immunol. 2014 Mar;175(3):449-57. doi: 10.1111/cei.12231.

• Laurdisen HM, Walker BJ, Gonzalez AL. Chemically- & mechanically tunable porated polyethylene glycol gels for integrin dependent and independent leukocyte chemotaxis. Technology. 2(2):133-143. 2014. doi: 10.1142/S2339547814500113

• Pu KM, Sava P, Gonzalez AL. Microvascular targets for anti-fibrotic therapeutics. Yale J Biol Med. 2013 Dec 13;86(4):537-54. PMID: 24348218; PMCID: PMC3848109.

• Lauridsen HM, Pober JS, Gonzalez AL. A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment. FASEB J. 2014 Mar;28(3):1166-80. doi: 10.1096/fj.13-240986.

• Ayres-Sander CE, Lauridsen H, Maier CL, Sava P, Pober JS, Gonzalez AL. Transendothelial migration enables subsequent transmigration of neutrophils through underlying pericytes. PLoS One. 2013;8(3):e60025. doi: 10.1371/journal.pone.0060025.

• Huang RB, Gonzalez AL, Eniola-Adefeso O. Laminar shear stress elicit distinct endothelial cell E-selectin expression pattern via TNFα and IL-1β activation. Biotechnol Bioeng. 2013 Mar;110(3):999-1003. doi: 10.1002/bit.24746.

• Padmanabhan J, Gonzalez AL. The effects of extracellular matrix proteins on neutrophil-endothelial interaction–a roadway to multiple therapeutic opportunities. Yale J Biol Med. 2012 Jun;85(2):167-85. Epub 2012 Jun 25. PMID: 22737047; PMCID: PMC3375712.

• Lee SK, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, Han L, Hyung JH, Seol JK, Sander C, Gonzalez A, Li J, Fan R. Nanowire substrate-based laser scanning cytometry for quantitation of circulating tumor cells. Nano Lett. 2012 Jun 13;12(6):2697-704. doi: 10.1021/nl2041707.

• Katz DL, Green LW, Murimi M, Gonzalez A, Njike V. The multisite translational community trial and community-based participatory research: a failure to communicate? Am J Public Health. 2012 Apr;102(4):581-2; author reply 582-3. doi: 10.2105/AJPH.2011.300490.

• Ayres-Sander, C.E., Gonzalez, A.L. Approaches in extracellular matrix engineering for determination of adhesion molecule mediated single cell function. Front. Biol. 8, 32–49 (2013). doi: 10.1007/s11515-012-1199-x

• Katz DL, Murimi M, Gonzalez A, Njike V, Green LW. From controlled trial to community adoption: the multisite translational community trial. Am J Public Health. 2011 Aug;101(8):e17-27. doi: 10.2105/AJPH.2010.300104.

• Njike V, Faridi Z, Dutta S, Gonzalez-Simon AL, Katz DL. Daily egg consumption in hyperlipidemic adults–effects on endothelial function and cardiovascular risk. Nutr J. 2010 Jul 2;9:28. doi: 10.1186/1475-2891-9-28.

• Gonzalez AL, El-Bjeirami W, West JL, McIntire LV, Smith CW. Transendothelial migration enhances integrin-dependent human neutrophil chemokinesis. J Leukoc Biol. 2007 Mar;81(3):686-95. doi: 10.1189/jlb.0906553.

• Gonzalez AL, Gobin AS, West JL, McIntire LV, Smith CW. Integrin interactions with immobilized peptides in polyethylene glycol diacrylate hydrogels. Tissue Eng. 2004 Nov-Dec;10(11-12):1775-86. doi: 10.1089/ten.2004.10.1775.